48,XXYY syndrome is a rare sex chromosome aneuploidy (SCA) condition affecting 1 in 18,000-40,000 male births. Clinical features include tall stature, hypergonadotropic hypogonadism (testosterone deficiency), infertility, developmental delays, learning disabilities, and intellectual impairment. Co-occurring behavior and mental health challenges are common in this population, with high rates of attention-deficit hyperactivity disorder (ADHD), anxiety, depression, sleep disorders, irritability,…
